Cholbam (cholic acid) capsules have been approved by the U.S. Food and Drug Administration to treat adults and children with bile acid synthesis disorders and peroxisomal disorders.
People with these rare disorders lack enzymes to process cholic acid, normally made by the liver from cholesterol.
This leads to reduced bile flow, potentially poisonous buildup of bile acid products in the liver and less absorption of fats and vitamins.
Left untreated, the disorders could cause deadly liver damage.
Cholbam is sanctioned for adults and children aged 3 weeks and older. The drug was evaluated in clinical studies involving some 79 people aged 3 weeks to 36 years. Two-thirds of people with bile synthesis disorders treated with the drug survived longer than three years. And 42 percent of people with peroxisomal disorders survived longer than three years.
Diarrhea was the most common side effect of the drug. Its use should be carefully monitored, and discontinued if the user's liver function worsens.
The agency said it is requiring a post-approval study to further evaluate Cholbam's long-term safety.
The drug is produced by Asklepion Pharmaceuticals, based in Baltimore.
Reference:
Food and Drug Administration - FDA / March 2015
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